A meta-analysis approach for characterizing pan-cancer mechanisms of drug sensitivity in cell lines.

A meta-analysis approach for characterizing pan-cancer mechanisms of drug sensitivity in cell lines.

Understanding the heterogeneous drug response of cancer patients is essential to precision oncology. Pioneering genomic analyses of individual cancer subtypes have begun to identify key determinants of resistance, including up-regulation of multi-drug resistance (MDR) genes and mutational alteration...

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Bibliographic Details
Main Authors: Kendric Wang, Raunak Shrestha, Alexander W Wyatt, Anupama Reddy, Joseph Lehár, Yuzhou Wang, Anna Lapuk, Colin C Collins
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4103868?pdf=render

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http://europepmc.org/articles/PMC4103868?pdf=render

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