Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells

Novel C-Terminal Heat Shock Protein 90 Inhibitors (KU711 and Ku757) Are Effective in Targeting Head and Neck Squamous Cell Carcinoma Cancer Stem cells

Advanced head and neck squamous cell carcinoma (HNSCC) remains a therapeutic challenge due to the development of therapy resistance. Several studies have implicated the development of cancer stem cells as a possible mechanism for therapy resistance in HNSCC. Heat shock protein 90’s (Hsp90’s) molecul...

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Bibliographic Details
Main Authors: C. Subramanian, K.J. Kovatch, M.W. Sim, G. Wang, M.E. Prince, T.E. Carey, R. Davis, B.S.J. Blagg, M.S. Cohen
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558617302610

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http://www.sciencedirect.com/science/article/pii/S1476558617302610

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