Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12207 |
| id |
doaj-99a9b5cebeca4de094483492341bfcd1 |
|---|---|
| record_format |
Article |
| spelling |
doaj-99a9b5cebeca4de094483492341bfcd12021-05-11T10:56:35ZengNature Publishing GroupNature Communications2041-17232016-08-017111310.1038/ncomms12207Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAsMaoyi Lai0Alicia Gonzalez-Martin1Anthony B. Cooper2Hiroyo Oda3Hyun Yong Jin4Jovan Shepherd5Linling He6Jiang Zhu7David Nemazee8Changchun Xiao9Department of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteDepartment of Immunology and Microbial Science, The Scripps Research InstituteMicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.https://doi.org/10.1038/ncomms12207 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Maoyi Lai Alicia Gonzalez-Martin Anthony B. Cooper Hiroyo Oda Hyun Yong Jin Jovan Shepherd Linling He Jiang Zhu David Nemazee Changchun Xiao |
| spellingShingle |
Maoyi Lai Alicia Gonzalez-Martin Anthony B. Cooper Hiroyo Oda Hyun Yong Jin Jovan Shepherd Linling He Jiang Zhu David Nemazee Changchun Xiao Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs Nature Communications |
| author_facet |
Maoyi Lai Alicia Gonzalez-Martin Anthony B. Cooper Hiroyo Oda Hyun Yong Jin Jovan Shepherd Linling He Jiang Zhu David Nemazee Changchun Xiao |
| author_sort |
Maoyi Lai |
| title |
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs |
| title_short |
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs |
| title_full |
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs |
| title_fullStr |
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs |
| title_full_unstemmed |
Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs |
| title_sort |
regulation of b-cell development and tolerance by different members of the mir-17∼92 family micrornas |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-08-01 |
| description |
MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim. |
| url |
https://doi.org/10.1038/ncomms12207 |
| work_keys_str_mv |
AT maoyilai regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT aliciagonzalezmartin regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT anthonybcooper regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT hiroyooda regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT hyunyongjin regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT jovanshepherd regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT linlinghe regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT jiangzhu regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT davidnemazee regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas AT changchunxiao regulationofbcelldevelopmentandtolerancebydifferentmembersofthemir1792familymicrornas |
| _version_ |
1721447314493538304 |