Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs
MicroRNA cluster 17∼92 plays a critical role in B-cell differentiation. Here the authors show that miR-19 regulates B-cell tolerance via suppressing the expression of PTEN, whereas miR- 17 is essential for early B-cell development independently of Pten, Phlpp2, or Bim.
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12207 |