Case Report: BAP1 Mutation and RAD21 Amplification as Predictive Biomarkers to PARP Inhibitor in Metastatic Intrahepatic Cholangiocarcinoma

Case Report: BAP1 Mutation and RAD21 Amplification as Predictive Biomarkers to PARP Inhibitor in Metastatic Intrahepatic Cholangiocarcinoma

IntroductionIntrahepatic cholangiocarcinoma (ICC) is a rare hepatobiliary cancer characterized by a poor prognosis and a limited response to conventional therapies. Currently chemotherapy is the only therapeutic option for patients with Stage IV ICC. Due to the poor response rate, there is an urgent...

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Bibliographic Details
Main Authors: Francesco Sabbatino, Luigi Liguori, Umberto Malapelle, Francesca Schiavi, Vincenzo Tortora, Valeria Conti, Amelia Filippelli, Giampaolo Tortora, Cristina R. Ferrone, Stefano Pepe
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Oncology
Subjects:
BAP1
precision oncology
cholangio carcinoma
Poly ADP ribose polymerase (PARP) inhibitor
RAD21
olaparib
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.567289/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.567289/full

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