Distinct Contribution of the HtrA Protease and PDZ Domains to Its Function in Stress Resilience and Virulence of Bacillus anthracis

Distinct Contribution of the HtrA Protease and PDZ Domains to Its Function in Stress Resilience and Virulence of Bacillus anthracis

Anthrax is a lethal disease caused by the Gram-positive spore-producing bacterium Bacillus anthracis. We previously demonstrated that disruption of htrA gene, encoding the chaperone/protease HtrABA (High Temperature Requirement A of B. anthracis) results in significant virulence attenuation, despite...

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Bibliographic Details
Main Authors: Ma’ayan Israeli, Uri Elia, Shahar Rotem, Hila Cohen, Avital Tidhar, Adi Bercovich-Kinori, Ofer Cohen, Theodor Chitlaru
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
Bacillus anthracis
HtrA protease
proteolytic domain
PDZ domain
auto-processing
virulence
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00255/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00255/full

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