Preclinical rodent toxicity studies for long term use of ceftriaxone

Preclinical rodent toxicity studies for long term use of ceftriaxone

A 6-months rodent toxicology and pharmacokinetic (PK) study was performed to provide supportive safety data for long-term use of intravenous ceftriaxone in a clinical trial in patients with amyotrophic lateral sclerosis (ALS). Ceftriaxone was administered by subcutaneous injection at up to 2 g/kg/da...

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Bibliographic Details
Main Authors: Elena Ratti, James D. Berry, David J. Greenblatt, Lorena Loci, Amy Swartz Ellrodt, Jeremy M. Shefner, Merit E. Cudkowicz
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Toxicology Reports
Subjects:
Ceftriaxone
Amyotrophic lateral sclerosis (ALS)
Rodent
Toxicology
Pharmacokinetics
Preclinical study
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750015300640

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http://www.sciencedirect.com/science/article/pii/S2214750015300640

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