Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model

Predictive Modeling of MAFLD Based on Hsp90α and the Therapeutic Application of Teprenone in a Diet-Induced Mouse Model

Background and AimsThe heat shock protein (Hsp) 90α is induced by stress and regulates inflammation through multiple pathways. Elevated serum Hsp90α had been found in nonalcoholic steatohepatitis (NASH). Geranylgeranylacetone (GGA, also called teprenone) is a terpenoid derivative. It was reported to...

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Bibliographic Details
Main Authors: Yuan Xie, Lu Chen, Zhipeng Xu, Chen Li, Yangyue Ni, Min Hou, Lin Chen, Hao Chang, Yuxuan Yang, Huiquan Wang, Rongbo He, Rourou Chen, Li Qian, Yan Luo, Ying Zhang, Na Li, Yuxiao Zhu, Minjun Ji, Yu Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Endocrinology
Subjects:
MAFLD
NASH
steatohepatitis
Hsp90α
teprenone
geranylgeranylacetone
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.743202/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.743202/full

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