LncRNA GAS5 as miR-26a-5p Sponge Regulates the PTEN/PI3K/Akt Axis and Affects Extracellular Matrix Synthesis in Degenerative Nucleus Pulposus Cells in vitro

LncRNA GAS5 as miR-26a-5p Sponge Regulates the PTEN/PI3K/Akt Axis and Affects Extracellular Matrix Synthesis in Degenerative Nucleus Pulposus Cells in vitro

The role of lncRNA growth arrest specific 5 (GAS5) in degenerative nucleus pulposus cell (NPC) apoptosis has been reported, but the mechanism of GAS5 in extracellular matrix (ECM) synthesis in intervertebral disc degeneration (IDD) remains unknown. We aimed to investigate the mechanism of GAS5 in EC...

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Bibliographic Details
Main Authors: Liang Tan, Yifang Xie, Ye Yuan, Kai Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Neurology
Subjects:
intervertebral disc degeneration
nucleus pulposus cells
lncRNA GAS5
miR-26a-5p
PTEN
extracellular matrix
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.653341/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2021.653341/full

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