When more is less: Emergent suppressive interactions in three-drug combinations

When more is less: Emergent suppressive interactions in three-drug combinations

Abstract Background In drug-drug interactions, there are surprising cases in which the growth inhibition of bacteria by a single antibiotic decreases when a second antibiotic is added. These interactions are termed suppressive and have been argued to have the potential to limit the evolution of resi...

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Bibliographic Details
Main Authors: Casey Beppler, Elif Tekin, Cynthia White, Zhiyuan Mao, Jeffrey H. Miller, Robert Damoiseaux, Van M. Savage, Pamela J. Yeh
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Microbiology
Subjects:
Higher-order interactions
Antagonism
Multiple stressors
Antibiotics
Drug resistance
Online Access:http://link.springer.com/article/10.1186/s12866-017-1017-3

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http://link.springer.com/article/10.1186/s12866-017-1017-3

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