Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (ABCA1), have been associated with AMD risk...

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Bibliographic Details
Main Authors: Federica Storti, Katrin Klee, Vyara Todorova, Regula Steiner, Alaa Othman, Saskia van der Velde-Visser, Marijana Samardzija, Isabelle Meneau, Maya Barben, Duygu Karademir, Valda Pauzuolyte, Sanford L Boye, Frank Blaser, Christoph Ullmer, Joshua L Dunaief, Thorsten Hornemann, Lucia Rohrer, Anneke den Hollander, Arnold von Eckardstein, Jürgen Fingerle, Cyrille Maugeais, Christian Grimm
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
ABCA1
retinal degeneration
retinal pigment epithelium
lipid efflux
age-related macular degeneration
ABCG1
Online Access:https://elifesciences.org/articles/45100

Internet

https://elifesciences.org/articles/45100

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