Structural features of apolipoprotein B synthetic peptides that inhibit lipoprotein(a) assembly

Lipoprotein(a) [Lp(a)] is assembled via an initial noncovalent interaction between apolipoprotein B100 (apoB) and apolipoprotein(a) [apo(a)] that facilitates the formation of a disulfide bond between the two proteins. We previously reported that a lysine-rich, α-helical peptide spanning human apoB a...

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Bibliographic Details
Main Authors: Rebecca J. Sharp, Matthew A. Perugini, Santica M. Marcovina, Sally P.A. McCormick
Format: Article
Language:English
Published: Elsevier 2004-12-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752034102X