Cutaneous epithelial tumors induced by vemurafenib involve the MAPK and Pi3KCA pathways but not HPV nor HPyV viral infection.

Cutaneous epithelial tumors induced by vemurafenib involve the MAPK and Pi3KCA pathways but not HPV nor HPyV viral infection.

The inhibitors of mutant BRAF that are used to treat metastatic melanoma induce squamoproliferative lesions. We conducted a prospective histopathological and molecular study on 27 skin lesions from 12 patients treated with vemurafenib. Mutation hot spots in HRAS, NRAS, KRAS, BRAF, and Pi3KCA were sc...

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Bibliographic Details
Main Authors: Eric Frouin, Bernard Guillot, Marion Larrieux, Ariane Tempier, Nathalie Boulle, Vincent Foulongne, Céline Girard, Valérie Costes, Jérome Solassol
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4215900?pdf=render

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http://europepmc.org/articles/PMC4215900?pdf=render

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