Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and Its Implications

Inflammatory Foreign Body Response Induced by Neuro-Implants in Rat Cortices Depleted of Resident Microglia by a CSF1R Inhibitor and Its Implications

Inflammatory encapsulation of implanted cortical-neuro-probes [the foreign body response (FBR)] severely limits their use in basic brain research and in clinical applications. A better understanding of the inflammatory FBR is needed to effectively mitigate these critical limitations. Combining the u...

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Bibliographic Details
Main Authors: Aviv Sharon, Maciej M. Jankowski, Nava Shmoel, Hadas Erez, Micha E. Spira
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
bioelectronics
neuro-implant
microglia
PLX5622
CSF1R
foreign body response
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.646914/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.646914/full

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