Uncovering Novel Pathways for Enhancing Hyaluronan Synthesis in Recombinant <i>Lactococcus lactis</i>: Genome-Scale Metabolic Modeling and Experimental Validation
Hyaluronan (HA), a glycosaminoglycan with important medical applications, is commercially produced from pathogenic microbial sources. The metabolism of HA-producing recombinant generally regarded as safe (GRAS) systems needs to be more strategically engineered to achieve yields higher than native pr...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-06-01
|
| Series: | Processes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9717/7/6/343 |