Ribozyme-Mediated Downregulation Uncovers DNA Integrity Scanning Protein A (DisA) as a Solventogenesis Determinant in Clostridium beijerinckii

Ribozyme-Mediated Downregulation Uncovers DNA Integrity Scanning Protein A (DisA) as a Solventogenesis Determinant in Clostridium beijerinckii

Carbon catabolite repression (CCR) limits microbial utilization of lignocellulose-derived pentoses. To relieve CCR in Clostridium beijerinckii NCIMB 8052, we sought to downregulate catabolite control protein A (CcpA) using the M1GS ribozyme technology. A CcpA-specific ribozyme was constructed by tet...

Full description

Bibliographic Details
Main Authors: Victor Chinomso Ujor, Lien B. Lai, Christopher Chukwudi Okonkwo, Venkat Gopalan, Thaddeus Chukwuemeka Ezeji
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
butanol
carbon catabolite repression
M1GS
solventogenesis
metabolic engineering
Clostridium beijerinckii
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.669462/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.669462/full

Similar Items