Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium

Calcium-activated anion secretion is expected to ameliorate cystic fibrosis, a genetic disease that carries an anion secretory defect in exocrine tissues. Human patients and animal models of the disease that present a mild intestinal phenotype have been postulated to bear a compensatory calcium-acti...

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Bibliographic Details
Main Authors: Génesis Vega, Anita Guequén, Malin E. V. Johansson, Liisa Arike, Beatriz Martínez-Abad, Elisabeth E. L. Nyström, Paolo Scudieri, Nicoletta Pedemonte, Pamela Millar-Büchner, Amber R. Philp, Luis J. Galietta, Gunnar C. Hansson, Carlos A. Flores
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Physiology
Subjects:
TMEM16A
cystic fibrosis transmembrane conductance regulator
epithelial transport
colon
intestinal mucus
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00694/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00694/full

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