Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree.

Sepsis is frequently complicated by a state of profound immunosuppression, in its extreme form known as immunoparalysis. We have studied the role of the adaptive immune system in the murine acute peritonitis model. To read out adaptive immunosuppression, we primed post-septic and control animals by...

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Bibliographic Details
Main Authors: Katrin Schmoeckel, Daniel M Mrochen, Jochen Hühn, Christian Pötschke, Barbara M Bröker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5802895?pdf=render