Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues.

Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues.

Human PDHA2 is a testis-specific gene that codes for the E(1)α subunit of Pyruvate Dehydrogenase Complex (PDC), a crucial enzyme system in cell energy metabolism. Since activation of the PDHA2 gene in somatic cells could be a new therapeutic approach for PDC deficiency, we aimed to identify the regu...

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Bibliographic Details
Main Authors: Ana Pinheiro, Maria João Nunes, Inês Milagre, Elsa Rodrigues, Maria João Silva, Isabel Tavares de Almeida, Isabel Rivera
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22675509/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22675509/pdf/?tool=EBI

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