Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media

Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media

Lentiviral vectors are increasingly utilized in cell and gene therapy applications because they efficiently transduce target cells such as hematopoietic stem cells and T cells. Large-scale production of current Good Manufacturing Practices-grade lentiviral vectors is limited because of the adherent,...

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Bibliographic Details
Main Authors: Matthew Bauler, Jessica K. Roberts, Chang-Chih Wu, Baochang Fan, Francesca Ferrara, Bon Ham Yip, Shiyong Diao, Young-In Kim, Jennifer Moore, Sheng Zhou, Matthew M. Wielgosz, Byoung Ryu, Robert E. Throm
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lentiviral
gene and cell therapy
HIV
scalable
lentivirus
production
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050119301366

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http://www.sciencedirect.com/science/article/pii/S2329050119301366

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