Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy

Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy

Most chemotherapy regimens contain at least one DNA-damaging agent that preferentially affects the growth of cancer cells. This strategy takes advantage of the differences in cell proliferation between normal and cancer cells. Chemotherapeutic drugs are usually designed to target rapid-dividing cell...

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Bibliographic Details
Main Authors: Yang Xu, Chengtao Her
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Biomolecules
Subjects:
topoisomerase (DNA) I (TOP1)
anticancer therapy
DNA replication
topoisomerase inhibitor
DNA double-strand break (DSB)
DSB repair
homologous recombination (HR)
non-homologous end joining
single-strand break (SSB) repair
one-ended DSB
Online Access:http://www.mdpi.com/2218-273X/5/3/1652

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http://www.mdpi.com/2218-273X/5/3/1652

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