Direct Synthesis of Polyaromatic Cyclophanes Containing Bis-Methylene-Interrupted <i>Z</i>-Double Bonds and Study of Their Antitumor Activity In Vitro

Direct Synthesis of Polyaromatic Cyclophanes Containing Bis-Methylene-Interrupted <i>Z</i>-Double Bonds and Study of Their Antitumor Activity In Vitro

An original synthetic route was developed for the preparation of previously unknown unsaturated polyaromatic macrolactones containing a 1Z,5Z-diene moiety in 48–71% yields and with >98% stereoselectivity. The method is based on intermolecular cyclocondensation of aromatic dicarboxylic acids with...

Full description

Bibliographic Details
Main Authors: Vladimir A. D’yakonov, Ilgiz I. Islamov, Lilya U. Dzhemileva, Elina Kh. Makarova, Usein M. Dzhemilev
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
cyclophanes
1,5-dienoic compounds
1,2-dienes
cyclomagnesiation
homogeneous catalysis
Online Access:https://www.mdpi.com/1422-0067/22/16/8787

Internet

https://www.mdpi.com/1422-0067/22/16/8787

Similar Items