Identification of pyrazolopyridazinones as PDEδ inhibitors

Identification of pyrazolopyridazinones as PDEδ inhibitors

PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with low cytotoxic side effects.

Bibliographic Details
Main Authors: Björn Papke, Sandip Murarka, Holger A Vogel, Pablo Martín-Gago, Marija Kovacevic, Dina C Truxius, Eyad K Fansa, Shehab Ismail, Gunther Zimmermann, Kaatje Heinelt, Carsten Schultz-Fademrecht, Alaa Al Saabi, Matthias Baumann, Peter Nussbaumer, Alfred Wittinghofer, Herbert Waldmann, Philippe I.H. Bastiaens
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11360

Internet

https://doi.org/10.1038/ncomms11360

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