Fructo-oligosaccharides alleviate inflammation-associated apoptosis of GLP-1 secreting L cells via inhibition of iNOS and cleaved caspase-3 expression

Fructo-oligosaccharides alleviate inflammation-associated apoptosis of GLP-1 secreting L cells via inhibition of iNOS and cleaved caspase-3 expression

Glucagon-like peptide 1 (GLP-1) released from enteroendocrine (L) cells regulates insulin secretion. Intestinal inflammation and impaired GLP-1 release have been found in type 2 diabetes mellitus (T2DM) patients. Fructo-oligosaccharides (FOS), a known prebiotic, improve GLP-1 release and glucose hom...

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Bibliographic Details
Main Authors: Preedajit Wongkrasant, Pawin Pongkorpsakol, Sasirin Chitwattananont, Wilasinee Satianrapapong, Nuttha Tuangkijkul, Chatchai Muanprasat
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Journal of Pharmacological Sciences
Subjects:
Type 2 diabetes mellitus
Glucagon-like peptide-1
Inflammation
L cells
Fructo-oligosaccharides
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861320300281

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http://www.sciencedirect.com/science/article/pii/S1347861320300281

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