Leukemia cell-derived microvesicles induce T cell exhaustion via miRNA delivery

Leukemia cell-derived microvesicles induce T cell exhaustion via miRNA delivery

T cell function in cancer patients is usually impaired due to the constitutive activation of immune checkpoint inhibitors. This state is known as ‘exhaustion’ and is often associated with the inefficient control of tumors or persistent infections. In this work, we investigated the role of leukemia c...

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Bibliographic Details
Main Authors: Jieke Cui, Qing Li, Mei Luo, Zhaodong Zhong, Shu Zhou, Lin Jiang, Na Shen, Zhe Geng, Hui Cheng, Li Meng, Shujuan Yi, Hui Sun, Feifei Wu, Zunmin Zhu, Ping Zou, Yong You, An-Yuan Guo, Xiaojian Zhu
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:OncoImmunology
Subjects:
microvesicles (mvs)
micrornas (mirnas)
nf-κb
serpinb2
t cell exhaustion
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1448330

Internet

http://dx.doi.org/10.1080/2162402X.2018.1448330

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