Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase

Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase

Abstract Although cellular prion protein PrPC is well known for its implication in Transmissible Spongiform Encephalopathies, its functions remain elusive. Combining in vitro and in vivo approaches, we here show that PrPC displays the intrinsic capacity to protect neuronal cells from a pro-inflammat...

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Bibliographic Details
Main Authors: Juliette Ezpeleta, François Boudet-Devaud, Mathéa Pietri, Anne Baudry, Vincent Baudouin, Aurélie Alleaume-Butaux, Nathalie Dagoneau, Odile Kellermann, Jean-Marie Launay, Benoit Schneider
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08110-x

Internet

https://doi.org/10.1038/s41598-017-08110-x

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