A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase

A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase

The Sleeping Beauty (SB) transposon system has been shown to enable long-term gene expression by integrating new sequences into host cell chromosomes. We found that the recently reported SB100x hyperactive transposase conferred a surprisingly high level of long-term expression after hydrodynamic del...

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Bibliographic Details
Main Authors: Kelly M Podetz-Pedersen, Erik R Olson, Nikunj V Somia, Stephen J Russell, R Scott McIvor
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
hydrodynamic
liver
Sleeping Beauty
transposase
transposon
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300100

Internet

http://www.sciencedirect.com/science/article/pii/S2162253117300100

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