Investigating the impact of reference assembly choice on genomic analyses in a cattle breed

Investigating the impact of reference assembly choice on genomic analyses in a cattle breed

Abstract Background Reference-guided read alignment and variant genotyping are prone to reference allele bias, particularly for samples that are greatly divergent from the reference genome. A Hereford-based assembly is the widely accepted bovine reference genome. Haplotype-resolved genomes that exce...

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Bibliographic Details
Main Authors: Audald Lloret-Villas, Meenu Bhati, Naveen Kumar Kadri, Ruedi Fries, Hubert Pausch
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Genomics
Subjects:
Reference genome comparison
Bovine
Alignment quality
Sequence variants
Functional annotation
Signatures of selection
Online Access:https://doi.org/10.1186/s12864-021-07554-w

Internet

https://doi.org/10.1186/s12864-021-07554-w

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