Preliminary Structural Elucidation of β-(1,3)-Glucan Synthase from <i>Candida glabrata</i> Using Cryo-Electron Tomography

Preliminary Structural Elucidation of β-(1,3)-Glucan Synthase from <i>Candida glabrata</i> Using Cryo-Electron Tomography

Echinocandin drugs have become a front-line therapy against <i>Candida</i> spp. infections due to the increased incidence of infections by species with elevated azole resistance, such as <i>Candida glabrata</i>. Echinocandins target the fungal-specific enzyme β-(1,3)-glucan s...

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Bibliographic Details
Main Authors: Cristina Jiménez-Ortigosa, Jennifer Jiang, Muyuan Chen, Xuyuan Kuang, Kelley R. Healey, Paul Castellano, Nikpreet Boparai, Steven J. Ludtke, David S. Perlin, Wei Dai
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Fungi
Subjects:
<i>Candida glabrata</i>
glucan synthase (GS)
cryo-electron tomography (cryoET)
Online Access:https://www.mdpi.com/2309-608X/7/2/120

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https://www.mdpi.com/2309-608X/7/2/120

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