Inhibitory Effects of Isoliquiritigenin and Licorice Extract on Voltage-Dependent K+ Currents in H9c2 Cells

The effect of isoliquiritigenin (ISL), a component of licorice, on the voltage-dependent, ultra-rapidly activating delayed-rectifier K+ current (IKur) was examined in H9c2 cells, a cell-line derived from rat cardiac myoblasts. IKur was recorded using the whole-cell patch clamp method with a pipette...

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Bibliographic Details
Main Authors: Chisato Noguchi, Jing Yang, Kazuho Sakamoto, Ryo Maeda, Kenji Takahashi, Hiroshi Takasugi, Tomoyuki Ono, Masahiro Murakawa, Junko Kimura
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319313167