LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo

LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's disease in humans in-vivo

Objective: Impaired amyloid clearance has been proposed to contribute to β-amyloid deposition in sporadic late-onset Alzheimer's disease (AD). Low density lipoprotein receptor-related protein 1 (LRP-1) is involved in the active outward transport of β-amyloid across the blood–brain barrier (BBB)...

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Bibliographic Details
Main Authors: Timo Grimmer, Oliver Goldhardt, Liang-Hao Guo, Behrooz H. Yousefi, Stefan Förster, Alexander Drzezga, Christian Sorg, Panagiotis Alexopoulos, Hans Förstl, Alexander Kurz, Robert Perneczky
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:NeuroImage: Clinical
Subjects:
Alzheimer's disease (AD)
Low density lipoprotein receptor related protein 1 (LRP-1)
C667T polymorphism
Apolipoprotein E (ApoE)
Pittsburgh compound B ([11C]PiB)
Positron emission tomography (PET)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158214000175

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http://www.sciencedirect.com/science/article/pii/S2213158214000175

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