BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

Abstract Background Metastasis is responsible for a significant number of breast cancer-related deaths. Hypoxia, a primary driving force of cancer metastasis, induces the expression of BHLHE40, a transcription regulator. This study aimed to elucidate the function of BHLHE40 in the metastatic process...

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Bibliographic Details
Main Authors: Aarti Sethuraman, Martin Brown, Raya Krutilina, Zhao-Hui Wu, Tiffany N. Seagroves, Lawrence M. Pfeffer, Meiyun Fan
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Breast Cancer Research
Subjects:
BHLHE40
Hypoxia
Breast cancer
Metastasis
Exosomes
HBEGF
Online Access:http://link.springer.com/article/10.1186/s13058-018-1046-3

Internet

http://link.springer.com/article/10.1186/s13058-018-1046-3

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