Time between milestone events in the Alzheimer's disease amyloid cascade
Objective: Estimate the time-course of the spread of key pathological markers and the onset of cognitive dysfunction in Alzheimer's disease. Methods: In a cohort of 335 older adults, ranging in cognitive functioning, we estimated the time of initial changes of Aβ, tau, and decreases in cognitio...
Main Authors: | Philip S. Insel, Michael C. Donohue, David Berron, Oskar Hansson, Niklas Mattsson-Carlgren |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-02-01
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Series: | NeuroImage |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811920311617 |
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