Decreased Human Leukocyte Antigen-G Expression by miR-133a Contributes to Impairment of Proinvasion and Proangiogenesis Functions of Decidual NK Cells

Decreased Human Leukocyte Antigen-G Expression by miR-133a Contributes to Impairment of Proinvasion and Proangiogenesis Functions of Decidual NK Cells

Human leukocyte antigen (HLA)-G plays a crucial role in conferring fetal–maternal tolerance and ensuring a successful pregnancy. CD56bright natural killer (NK) cells accumulate at the maternal decidua in large numbers during pregnancy and are found in direct contact with fetal trophoblasts. There ar...

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Bibliographic Details
Main Authors: Wenwei Guo, Liang Fang, Bo Li, Xifeng Xiao, Shuqiang Chen, Jun Wang, Fang Yang, Lihua Chen, Xiaohong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
miR-133a
human leukocyte antigen-G
decidua
nature killer cell
killer immunoglobulin-like receptor 2DL4
recurrent spontaneous abortion
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00741/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00741/full

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