TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment

TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment

Alzheimer disease (AD) is a devastating neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta and formation of intracellular neurofibrillary tangles. Microglia activation and neuroinflammation play important roles in the pathogenesis of AD; Toll-like receptor 4 (TLR4...

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Bibliographic Details
Main Authors: Yongji Zhou, Yanxing Chen, Congcong Xu, Hao Zhang, Caixiu Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
toll-like receptor 4
neuroinflammation
microglia
therapeutic target
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.602508/full
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spelling doaj-9854e5faa0cf4e70ac2d5ff5c0b7ecce2020-12-18T06:13:45ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2020-12-011410.3389/fnins.2020.602508602508TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease TreatmentYongji Zhou0Yanxing Chen1Congcong Xu2Hao Zhang3Caixiu Lin4Department of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaThe First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Neurology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaAlzheimer disease (AD) is a devastating neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta and formation of intracellular neurofibrillary tangles. Microglia activation and neuroinflammation play important roles in the pathogenesis of AD; Toll-like receptor 4 (TLR4)—a key component of the innate immune system—in microglia is also thought to be involved based on the observed association between TLR gene polymorphisms and AD risk. TLR4 has been shown to exert both detrimental and beneficial effects on AD-related pathologies. In preclinical models, experimental manipulations targeting TLR4 were shown to improve learning and memory, which was related to inhibition of pro-inflammatory cytokine release and reduction of oxidative stress. In this review, we summarize the key evidence supporting TLR4 as a promising therapeutic target in AD treatment.https://www.frontiersin.org/articles/10.3389/fnins.2020.602508/fullAlzheimer’s diseasetoll-like receptor 4neuroinflammationmicrogliatherapeutic target
collection DOAJ
language English
format Article
sources DOAJ
author Yongji Zhou
Yanxing Chen
Congcong Xu
Hao Zhang
Caixiu Lin
spellingShingle Yongji Zhou
Yanxing Chen
Congcong Xu
Hao Zhang
Caixiu Lin
TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
Frontiers in Neuroscience
Alzheimer’s disease
toll-like receptor 4
neuroinflammation
microglia
therapeutic target
author_facet Yongji Zhou
Yanxing Chen
Congcong Xu
Hao Zhang
Caixiu Lin
author_sort Yongji Zhou
title TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
title_short TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
title_full TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
title_fullStr TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
title_full_unstemmed TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
title_sort tlr4 targeting as a promising therapeutic strategy for alzheimer disease treatment
publisher Frontiers Media S.A.
series Frontiers in Neuroscience
issn 1662-453X
publishDate 2020-12-01
description Alzheimer disease (AD) is a devastating neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta and formation of intracellular neurofibrillary tangles. Microglia activation and neuroinflammation play important roles in the pathogenesis of AD; Toll-like receptor 4 (TLR4)—a key component of the innate immune system—in microglia is also thought to be involved based on the observed association between TLR gene polymorphisms and AD risk. TLR4 has been shown to exert both detrimental and beneficial effects on AD-related pathologies. In preclinical models, experimental manipulations targeting TLR4 were shown to improve learning and memory, which was related to inhibition of pro-inflammatory cytokine release and reduction of oxidative stress. In this review, we summarize the key evidence supporting TLR4 as a promising therapeutic target in AD treatment.
topic Alzheimer’s disease
toll-like receptor 4
neuroinflammation
microglia
therapeutic target
url https://www.frontiersin.org/articles/10.3389/fnins.2020.602508/full
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AT haozhang tlr4targetingasapromisingtherapeuticstrategyforalzheimerdiseasetreatment
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