TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment

TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment

Alzheimer disease (AD) is a devastating neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta and formation of intracellular neurofibrillary tangles. Microglia activation and neuroinflammation play important roles in the pathogenesis of AD; Toll-like receptor 4 (TLR4...

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Bibliographic Details
Main Authors: Yongji Zhou, Yanxing Chen, Congcong Xu, Hao Zhang, Caixiu Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
toll-like receptor 4
neuroinflammation
microglia
therapeutic target
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2020.602508/full

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https://www.frontiersin.org/articles/10.3389/fnins.2020.602508/full

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