A Simple Model to Study Tau Pathology

Tau proteins play a role in the stabilization of microtubules, but in pathological conditions, tauopathies, tau is modified by phosphorylation and can aggregate into aberrant aggregates. These aggregates could be toxic to cells, and different cell models have been used to test for compounds that mig...

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Bibliographic Details
Main Authors: Alexander L. Houck, Félix Hernández, Jesús Ávila
Format: Article
Language:English
Published: SAGE Publishing 2016-01-01
Series:Journal of Experimental Neuroscience
Online Access:https://doi.org/10.4137/JEN.S25100