Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus than Sequential Immunization

Simultaneous Immunization with Multivalent Norovirus VLPs Induces Better Protective Immune Responses to Norovirus than Sequential Immunization

Human noroviruses (NoVs) are a genetically diverse, constantly evolving group of viruses. Here, we studied the effect of NoV pre-existing immunity on the success of NoV vaccinations with genetically close and distant genotypes. A sequential immunization as an alternative approach to multivalent NoV...

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Bibliographic Details
Main Authors: Maria Malm, Timo Vesikari, Vesna Blazevic
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Viruses
Subjects:
norovirus
vlp
vaccine
genotype
pre-existing immunity
cross-reactivity
blocking antibodies
original antigenic sin (oas)
Online Access:https://www.mdpi.com/1999-4915/11/11/1018

Internet

https://www.mdpi.com/1999-4915/11/11/1018

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