Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice

Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice

Abstract Background Maternal smoking of traditional or electronic cigarettes during pregnancy, which constitutes developmental nicotine exposure (DNE), heightens the risk of neurodevelopmental disorders including ADHD, autism, and schizophrenia in children. Modeling the intergenerationally transmiss...

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Bibliographic Details
Main Authors: Jordan M. Buck, Heidi C. O’Neill, Jerry A. Stitzel
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Epigenetics & Chromatin
Subjects:
Nicotine
Neurodevelopment
Multigenerational
DNMT3A
TET2
MeCP2
Online Access:http://link.springer.com/article/10.1186/s13072-020-00332-0

Internet

http://link.springer.com/article/10.1186/s13072-020-00332-0

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