Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

Lipopolysaccharide induces neuroinflammation in microglia by activating the MTOR pathway and downregulating Vps34 to inhibit autophagosome formation

Abstract Background Microglial activation is a prominent feature of neuroinflammation, which is present in almost all neurodegenerative diseases. While an initial inflammatory response mediated by microglia is considered to be protective, excessive pro-inflammatory response of microglia contributes...

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Bibliographic Details
Main Authors: Xiaoxia Ye, Mingming Zhu, Xiaohang Che, Huiyang Wang, Xing-Jie Liang, Chunfu Wu, Xue Xue, Jingyu Yang
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Journal of Neuroinflammation
Subjects:
Lipopolysaccharide
Microglia
Autophagy
MTOR
Vps34
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-019-1644-8

Internet

https://doi.org/10.1186/s12974-019-1644-8

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