Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors

Epinephrine Released During Traumatic Events May Strengthen Contextual Fear Memory Through Increased Hippocampus mRNA Expression of Nr4a Transcription Factors

Epinephrine (EPI) strengthens contextual fear memories by acting on peripheral β2-adrenoceptors. Phenylethanolamine-N-methyltransferase-knockout (Pnmt-KO) mice are EPI-deficient mice and have reduced contextual fear learning. Our aim was to evaluate the molecular mechanisms by which peripheral EPI s...

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Bibliographic Details
Main Authors: Ana Oliveira, Raquel Martinho, Paula Serrão, Mónica Moreira-Rodrigues
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Molecular Neuroscience
Subjects:
epinephrine
contextual fear memory
traumatic experience
β2-adrenoceptors
Nr4a transcription factors
phenylethanolamine-N-methyltransferase-knockout mice
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00334/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00334/full

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