Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells.

Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells.

Many chronic infections, including malaria and HIV, are associated with a large expansion of CD21-CD27- 'atypical' memory B cells (MBCs) that exhibit reduced B cell receptor (BCR) signaling and effector functions. Little is known about the conditions or transcriptional regulators driving a...

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Bibliographic Details
Main Authors: Nyamekye Obeng-Adjei, Silvia Portugal, Prasida Holla, Shanping Li, Haewon Sohn, Abhijit Ambegaonkar, Jeff Skinner, Georgina Bowyer, Ogobara K Doumbo, Boubacar Traore, Susan K Pierce, Peter D Crompton
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1006576

Internet

https://doi.org/10.1371/journal.ppat.1006576

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