Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations

Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations

Bibliographic Details
Main Authors: Giulia Palermo, Yinglong Miao, Ross C. Walker, Martin Jinek, J. Andrew McCammon
Format: Article
Language:English
Published: American Chemical Society 2016-09-01
Series:ACS Central Science
Online Access:http://dx.doi.org/10.1021/acscentsci.6b00218
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spelling doaj-97e657e0acd8430d803137aa6503b94a2020-11-25T03:32:25ZengAmerican Chemical SocietyACS Central Science2374-79432374-79512016-09-0121075676310.1021/acscentsci.6b00218Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular SimulationsGiulia Palermo0Yinglong Miao1Ross C. Walker2Martin Jinek3J. Andrew McCammon4Department of Pharmacology, University of California San Diego, La Jolla, California, United StatesDepartment of Pharmacology, University of California San Diego, La Jolla, California, United StatesSan Diego Supercomputer Center, University of California San Diego, La Jolla, California, United StatesDepartment of Biochemistry, University of Zurich, Zurich, SwitzerlandDepartment of Pharmacology, University of California San Diego, La Jolla, California, United Stateshttp://dx.doi.org/10.1021/acscentsci.6b00218
collection DOAJ
language English
format Article
sources DOAJ
author Giulia Palermo
Yinglong Miao
Ross C. Walker
Martin Jinek
J. Andrew McCammon
spellingShingle Giulia Palermo
Yinglong Miao
Ross C. Walker
Martin Jinek
J. Andrew McCammon
Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
ACS Central Science
author_facet Giulia Palermo
Yinglong Miao
Ross C. Walker
Martin Jinek
J. Andrew McCammon
author_sort Giulia Palermo
title Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
title_short Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
title_full Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
title_fullStr Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
title_full_unstemmed Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
title_sort striking plasticity of crispr-cas9 and key role of non-target dna, as revealed by molecular simulations
publisher American Chemical Society
series ACS Central Science
issn 2374-7943
2374-7951
publishDate 2016-09-01
url http://dx.doi.org/10.1021/acscentsci.6b00218
work_keys_str_mv AT giuliapalermo strikingplasticityofcrisprcas9andkeyroleofnontargetdnaasrevealedbymolecularsimulations
AT yinglongmiao strikingplasticityofcrisprcas9andkeyroleofnontargetdnaasrevealedbymolecularsimulations
AT rosscwalker strikingplasticityofcrisprcas9andkeyroleofnontargetdnaasrevealedbymolecularsimulations
AT martinjinek strikingplasticityofcrisprcas9andkeyroleofnontargetdnaasrevealedbymolecularsimulations
AT jandrewmccammon strikingplasticityofcrisprcas9andkeyroleofnontargetdnaasrevealedbymolecularsimulations
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