Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy

Cultivation of Clear Cell Renal Cell Carcinoma Patient-Derived Organoids in an Air-Liquid Interface System as a Tool for Studying Individualized Therapy

Clear cell renal cell carcinoma (ccRCC) is the most common renal cancer accounting for 80% of all renal cancers as well as the majority of renal cancer-associated deaths. During the last decade, the treatment paradigm for ccRCC has radically changed. In particular, the recent development of immune c...

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Bibliographic Details
Main Authors: Laura K. Esser, Vittorio Branchi, Sonia Leonardelli, Natalie Pelusi, Adrian G. Simon, Niklas Klümper, Jörg Ellinger, Stefan Hauser, Maria A. Gonzalez-Carmona, Manuel Ritter, Glen Kristiansen, Hubert Schorle, Michael Hölzel, Marieta I. Toma
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
RCC
organoid
ccRCC
pRCC
targeted therapy
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01775/full

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