FTO Intronic SNP Strongly Influences Human Neck Adipocyte Browning Determined by Tissue and PPARγ Specific Regulation: A Transcriptome Analysis

FTO Intronic SNP Strongly Influences Human Neck Adipocyte Browning Determined by Tissue and PPARγ Specific Regulation: A Transcriptome Analysis

Brown adipocytes, abundant in deep-neck (DN) area in humans, are thermogenic with anti-obesity potential. FTO pro-obesity rs1421085 T-to-C single-nucleotide polymorphism (SNP) shifts differentiation program towards white adipocytes in subcutaneous fat. Human adipose-derived stromal cells were obtain...

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Bibliographic Details
Main Authors: Beáta B. Tóth, Rini Arianti, Abhirup Shaw, Attila Vámos, Zoltán Veréb, Szilárd Póliska, Ferenc Győry, Zsolt Bacso, László Fésüs, Endre Kristóf
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
adipocyte browning
differential gene expression patterns
deep-neck
PPARγ
FTO obesity-risk allele
Online Access:https://www.mdpi.com/2073-4409/9/4/987

Internet

https://www.mdpi.com/2073-4409/9/4/987

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