Improvement of the Targeting of Radiolabeled and Functionalized Liposomes with a Two-Step System Using a Bispecific Monoclonal Antibody (Anti-CEA × Anti-DTPA–In)

Improvement of the Targeting of Radiolabeled and Functionalized Liposomes with a Two-Step System Using a Bispecific Monoclonal Antibody (Anti-CEA × Anti-DTPA–In)

This study proposes liposomes as a new tool for pretargeted radioimmunotherapy (RIT) in solid tumors. Tumor pretargeting is obtained by using a bispecific monoclonal antibody (BsmAb, anti-CEA x anti-DTPA-In) and pegylated radioactive liposomes containing a lipid-hapten conjugate (DSPE-PEG-DTPA-In)....

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Bibliographic Details
Main Authors: Aurore eRauscher, Mathieu eFrindel, Holisoa eRajérison, Sébastien eGouard, Catherine eMaurel, Jacques eBarbet, Alain eFaivre-Chauvet, Marie eMougin-Degraef
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Medicine
Subjects:
Radioimmunotherapy
solid tumors
pretargeting
bispecific antibody
PEGylated liposomes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00083/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmed.2015.00083/full

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