Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever

Endotheliopathy and Platelet Dysfunction as Hallmarks of Fatal Lassa Fever

Lassa fever (LF) causes multisystem disease and has a fatality rate <70%. Severe cases exhibit abnormal coagulation, endothelial barrier disruption, and dysfunctional platelet aggregation but the underlying mechanisms remain poorly understood. In Sierra Leone during 2015–2018, we assessed LF pat...

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Bibliographic Details
Main Authors: Lucy E. Horton, Robert W. Cross, Jessica N. Hartnett, Emily J. Engel, Saori Sakabe, Augustine Goba, Mambu Momoh, John Demby Sandi, Thomas W. Geisbert, Robert F. Garry, John S. Schieffelin, Donald S. Grant, Brian M. Sullivan
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2020-11-01
Series:Emerging Infectious Diseases
Subjects:
Lassa fever
hemostasis
platelet
protein C
coagulation
fibrinolysis
Online Access:https://wwwnc.cdc.gov/eid/article/26/11/19-1694_article

Internet

https://wwwnc.cdc.gov/eid/article/26/11/19-1694_article

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