Population Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study

Population Pharmacokinetic Characteristics of Amikacin in Suspected Cases of Neonatal Sepsis in a Low-Resource African Setting: A Prospective Nonrandomized Single-Site Study

Background: Amikacin exhibits marked pharmacokinetic (PK) variability and is commonly used in combination with other drugs in the treatment of neonatal sepsis. There is a paucity of amikacin PK information in neonates from low-resource settings. Objectives: To determine the PK parameters of amikacin...

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Bibliographic Details
Main Authors: Seth K. Amponsah, PhD, George O. Adjei, MD, PhD, Christabel Enweronu-Laryea, MRCPCH, Kwasi A. Bugyei, PhD, Kosta Hadji-Popovski, MSc Pharm, Jorgen A.L. Kurtzhals, MD, PhD, Kim Kristensen, PhD
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Current Therapeutic Research
Subjects:
aminoglycoside
clearance
distribution
sepsis
Online Access:http://www.sciencedirect.com/science/article/pii/S0011393X16300765

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http://www.sciencedirect.com/science/article/pii/S0011393X16300765

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