EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.

Bibliographic Details
Main Authors:	Nicolas Istaces, Marion Splittgerber, Viviana Lima Silva, Muriel Nguyen, Séverine Thomas, Aurore Le, Younes Achouri, Emilie Calonne, Matthieu Defrance, François Fuks, Stanislas Goriely, Abdulkader Azouz
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-11233-6

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spelling	doaj-977399acbe71487ca1c96fd6df9b20922021-05-11T11:49:56ZengNature Publishing GroupNature Communications2041-17232019-07-0110111710.1038/s41467-019-11233-6EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogrammingNicolas Istaces0Marion Splittgerber1Viviana Lima Silva2Muriel Nguyen3Séverine Thomas4Aurore Le5Younes Achouri6Emilie Calonne7Matthieu Defrance8François Fuks9Stanislas Goriely10Abdulkader Azouz11Université Libre de Bruxelles, Institute for Medical Immunology (IMI)Université Libre de Bruxelles, Institute for Medical Immunology (IMI)Université Libre de Bruxelles, Institute for Medical Immunology (IMI)Université Libre de Bruxelles, Institute for Medical Immunology (IMI)Université Libre de Bruxelles, Institute for Medical Immunology (IMI)Université Libre de Bruxelles, Institute for Medical Immunology (IMI)Université Catholique de Louvain, Institut de DuveUniversité Libre de Bruxelles, Laboratory of Cancer EpigeneticsUniversité Libre de Bruxelles, Interuniversity Institute of Bioinformatics in Brussels (IB2)Université Libre de Bruxelles, Laboratory of Cancer EpigeneticsUniversité Libre de Bruxelles, Institute for Medical Immunology (IMI)Université Libre de Bruxelles, Institute for Medical Immunology (IMI)T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.https://doi.org/10.1038/s41467-019-11233-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Nicolas Istaces Marion Splittgerber Viviana Lima Silva Muriel Nguyen Séverine Thomas Aurore Le Younes Achouri Emilie Calonne Matthieu Defrance François Fuks Stanislas Goriely Abdulkader Azouz
spellingShingle	Nicolas Istaces Marion Splittgerber Viviana Lima Silva Muriel Nguyen Séverine Thomas Aurore Le Younes Achouri Emilie Calonne Matthieu Defrance François Fuks Stanislas Goriely Abdulkader Azouz EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming Nature Communications
author_facet	Nicolas Istaces Marion Splittgerber Viviana Lima Silva Muriel Nguyen Séverine Thomas Aurore Le Younes Achouri Emilie Calonne Matthieu Defrance François Fuks Stanislas Goriely Abdulkader Azouz
author_sort	Nicolas Istaces
title	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_short	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_full	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_fullStr	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_full_unstemmed	EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming
title_sort	eomes interacts with runx3 and brg1 to promote innate memory cell formation through epigenetic reprogramming
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-07-01
description	T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.
url	https://doi.org/10.1038/s41467-019-11233-6
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EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

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