EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

EOMES interacts with RUNX3 and BRG1 to promote innate memory cell formation through epigenetic reprogramming

T box transcription factor Eomesodermin (EOMES) is induced when naïve T cells are converted to innate memory T cells in response to cytokines. Here the authors show that EOMES is recruited to RUNX3-bound enhancers and interacts with BRG1 during innate memory T cell formation.

Bibliographic Details
Main Authors: Nicolas Istaces, Marion Splittgerber, Viviana Lima Silva, Muriel Nguyen, Séverine Thomas, Aurore Le, Younes Achouri, Emilie Calonne, Matthieu Defrance, François Fuks, Stanislas Goriely, Abdulkader Azouz
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11233-6

Internet

https://doi.org/10.1038/s41467-019-11233-6

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